Psychosis Research Today is a free monthly online journal that collates and summarizes the latest research about Psychosis, including details on clinical depression, schizophrenia, bipolar disorder.

Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.

Lowenhaupt EA, Matson K, Qureishi B, Saitoh A, Pugatch D

Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. elowenhaupt@post.harvard.edu

Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

Published 30 October 2007 in Clin Infect Dis, 45(10): e128-30.
Full-text of this article is available online (may require subscription).

© 2005-2008 Psychosis Research Today. All Rights Reserved.