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Usher syndrome with psychotic symptoms: two cases in the same family.

Wu CY, Chiu CC

Department of Psychiatry, Taipei City Psychiatric Center, Taipei, Taiwan.

Usher syndrome is a heterogeneous autosomal recessive disorder characterized by hearing and visual sensory impairment. Retinitis pigmentosa is essential for its diagnosis. There are only a few reports describing patients with Usher syndrome presenting with psychotic features and the etiology of its psychiatric manifestation is still unknown. Herein, the authors report variable congenital hearing impairment and progressive visual loss occurring in five of seven family members and two of them meeting the diagnostic criteria of Usher syndrome with psychotic features. Furthermore, the authors compare their psychiatric symptoms with other reports and the possible etiologies of psychotic symptoms are discussed.

Published 8 September 2006 in Psychiatry Clin Neurosci, 60(5): 626-8.
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