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Benefits of combining aripiprazole to clozapine: three case reports.

Rocha FL, Hara C

Rua dos Otoni, 106, Santa Efigênia, 30150.270, Belo Horizonte, MG, Brazil. rochafl@uol.com.br

OBJECTIVE: A substantial number of patients treated with clozapine shows insufficient response. The author presents the results of adding aripiprazole in patients resistant to clozapine. METHOD: Three cases of individuals with psychotic symptoms despite clozapine use and with significant side effects that were treated via this combination are presented. Response was evaluated by clinical assessment. RESULTS: Good clinical results were obtained in all three patients, with improvement of psychotic symptoms and of some of the side effects of clozapine. CONCLUSION: The findings from this case series suggest that adjunctive therapy with aripiprazole can be of benefit for treating clozapine resistant schizophrenic patients.

Published 3 July 2006 in Prog Neuropsychopharmacol Biol Psychiatry, 30(6): 1167-9.
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