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Cognitive performance in presumed obligate carriers for psychosis.

Toulopoulou T, Mapua-Filbey F, Quraishi S, Kravariti E, Morris RG, McDonald C, Walshe M, Bramon E, Murray RM

Division of Psychological Medicine, Institute of Psychiatry, London, UK. t.toulopoulou@iop.kcl.ac.uk

We report cognitive performance of a group of individuals who are likely to have transmitted liability to psychosis to their offspring. Out of 230 relatives of patients with psychosis, 27 met our criteria for a presumed obligate carrier, that is a non-psychotic individual who had a parent or a sibling as well as an offspring with psychosis. The presumed obligate carriers showed impairments in verbal memory and in visuospatial manipulations, suggesting that these individuals transmit vulnerability for psychosis to their offspring in terms of a disability to recall verbal information and an impaired capacity to perceive spatial relations.

Published 1 September 2005 in Br J Psychiatry, 187: 284-5.
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