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The psychotic spectrum: validity and reliability of the Structured Clinical Interview for the Psychotic Spectrum.

Sbrana A, Dell'Osso L, Benvenuti A, Rucci P, Cassano P, Banti S, Gonnelli C, Doria MR, Ravani L, Spagnolli S, Rossi L, Raimondi F, Catena M, Endicott J, Frank E, Kupfer DJ, Cassano GB

Department of Psychiatry, University of Pisa, Via Roma 67, 56127 Pisa, Italy. alfredosbrana@virgilio.it

This study evaluates the validity and the reliability of a new instrument developed to assess the psychotic spectrum: the Structured Clinical Interview for the Psychotic Spectrum (SCI-PSY). The instrument is based on a spectrum model that emphasizes soft signs, low-grade symptoms, subthreshold syndromes, as well as temperamental and personality traits comprising the clinical and subsyndromal psychotic manifestations. The items of the interview include, in addition to a subset of the DSM-IV criteria for psychotic syndromes, a number of features derived from clinical experience and from a review of the phenomenological descriptions of psychoses. Study participants were enrolled at 11 Italian Departments of Psychiatry located at 9 sites and included 77 consecutive patients with schizophrenia or schizoaffective disorder, 66 with borderline personality disorder, 59 with psychotic mood disorders, 98 with non-psychotic mood disorders and 57 with panic disorder. A comparison group of 102 unselected controls was enrolled at the same sites. The SCI-PSY significantly discriminated subjects with any psychiatric diagnosis from controls and subjects with from those without psychotic disorders. The hypothesized structure of the instrument was confirmed empirically.

Published 11 May 2005 in Schizophr Res, 75(2): 375-87.
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